Education
Biology/Psychology, B.S. (1973), University of Pittsburgh, Pittsburgh, PA
Neurobiology, Ph.D. (1977), University of North Carolina, Chapel Hill, NC
Pharmacology and Toxicology, Postdoctoral (1977-1980), University of Chicago, Chicago, IL
Research Foci
- Intersection of toxicology and neuroscience at the level of behavior and neurochemistry
- Evaluation of 5-HT1A agonists for the ability to rescue the CNS from toxicities produced by sarin poisoning. Funded by DoD (JSTO/DTRA)
My research approach is to evaluate the interactions between behavior, drugs, and brain chemistry. This approach provides the flexibility to undertake a wide range of projects, to pursue interesting findings, and join in collaborative research. The laboratory is currently involved in the discovery of novel approaches to protect the civilian and military populations from neural damage produced by chemical warfare nerve agents. We have determined the toxic dose of sarin for our studies and characterized its effects on histopathology, inhibition of acetylcholinesterase in different brain regions, acute behavioral symptoms and its ability to inhibit fear conditioning. Using this baseline toxicity, we will characterize different agonists at the 5-HT1A receptor for their ability to reverse the toxic effects. We are also interested in how long after the poisoning the drug can be administered and provide protection. The results will also be applicable to emergency room treatment of pesticide poisoning.
Selected Publications
Mach, M., R.D. Grubbs, W.A. Price, M. Nagoaka, M. Dubovicky and J.B. Lucot. Delayed effect of subacute low-dose exposure to sarin combined with chronic intermittent shaker stress in mice. J. Appl. Tox. Submitted, 2007.
Dubovicky, M., S. Paton, M. Morris, M. Mach, J.B. Lucot. Effects of combined exposure to pyridostigmine bromide and shaker stress on acoustic startle response, pre-pulse inhibition and open field behavior in mice. J. Appl. Tox., in press, 2007.
Lucot, J.B., N. Jackson, I. Bernatova, M. Morris. Measurement of plasma catecholamines in small samples from mice. J. Pharmacol. Toxicol. Methods, 52: 2274-277, 2005.
Mach, M, R.D. Grubbs, W.A. Price, S. Paton, J.B. Lucot. Behavioral changes after acetylcholinesterase inhibition by physostigmine in C57bl/6J mice. Pharmacol. Biochem. Behav., 79:533-540, 2004.
Bernatova, I, M. Dubovicky, W.A. Price, R.D. Grubbs, J.B. Lucot, M. Morris. Effect of chronic pyridostigmine bromide treatment on cardiovascular and behavioral parameters in mice. Pharmacol. Biochem. Behav. 74(4): 901-907, 2003.
Bernatova, I, M.P. Key, J.B. Lucot, M. Morris. Circadian differences in stress-induced pressor reactivity in mice. Hypertension 40:768-773, 2002.
Harvey, A.T., Moore, H., Lucot, J.B. and Hennessy, M.B. Monoamine activity in anterior hypothalamus of guinea pig pups separated from their mothers. Beh. Neurosci., 108:171-176, 1994.
Foreman, M.M., Fuller, R.W., Leander, J.D., Benvenga, M.J., Wong, D.T., Nelson, D.L., Calligaro, D.O., Swanson, S.P., Lucot, J.B. and Flaugh, M.E. Preclinical studies on LY228729: a potent and selective 5-HT1A agonist. J. Pharmacol. Exp. Ther., 267:58-71, 1993.
Lucot, J.B., van Charldorp, K.J. and Tulp, M.Th.M. Idaverine, an M2 vs. M3 selective muscarinic antagonist, does not prevent motion sickness in cats. Pharmacol. Biochem. Behav., 40:345-349, 1991. [Abstract]
Tamborski, A., Lucot, J.B. and Hennessy, M.B.: Central dopamine turnover in guinea pig pups separated from their mothers in a novel environment. Behav. Neurosci., 104:607-611, 1990.
Lucot, J.B.: RU 24969-induced emesis in the cat: 5-HT1 sites other that 5-HT1A, 5-HT1B, or 5-HT1C implicated. Eur. J. Pharmacol., 180:193-199, 1990. [Abstract]
For more information, contact:
James Lucot, Ph.D.
Associate
Professor
Department of Pharmacology and Toxicology
Boonshoft School of Medicine
Wright State University
3640 Colonel Glenn Hwy.
Dayton, OH 45435-0001
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