J. Ashot Kozak, Ph.D.

Assistant Professor

Address: 148A Biological Sciences II
Phone: (937) 775-4514
E-mail: juliusz.kozak@wright.edu

Ph.D.: Mount Sinai School of Medicine
New York City, 1998

Research Interests

Cation channels expressed in leukocytes; Transient Receptor Potential (TRP) channels; ion channels involved in nociception.

Funding

Scientist Development Grant, American Heart Association, National Center

Teaching

Human Physiology, BMS862: Immunity, Blood, Molecular Endocrinology

Neuroscience and Physiology, BMS 875: Pain and Ion Channels, Control of Intracellular Calcium

Endocrine SMD 561: Physiology of Parathyroid Glands

Service

Chair, Biomedical Sciences Ph.D. Program Admissions Committee

Selected Publications

Chokshi, R. H., Matsushita, M., Kozak, J.A. (2012) Detailed examination of Mg²⁺ and pH sensitivity of human TRPM7 channels. Am. J. Physiol. Cell Physiol., in press.

Chokshi, R. H., Matsushita, M., Kozak, J.A. (2012) Sensitivity of TRPM7 channels to Mg²⁺ characterized in cell-free patches of Jurkat T lymphocytes. Am. J. Physiol. Cell Physiol., in press.

Zhang S.L.*, Kozak J.A.*, Jiang W., Yu Y., Penna, A., Chi V., Cahalan, M.D. (2008) Functional requirements for expression of Orai and STIM homologs in regulating mammalian CRAC channel activity. J. Biol. Chem 283:17662. *equal contributions

Lioudyno M.I., Kozak, J.A., Penna A., Safrina O., Zhang S.L., Roos J., Stauderman K.A., Cahalan M.D. (2008) Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. Proc. Natl. Acad. Sci. USA 105(6):2011

Jovanovska, A., Karczewski, J., Cook, S. and Kozak J.A. (2007) Regulation of proton-activated ASIC1 channels by extracellular organic cations. Society for Neurosci. Annual Meeting Abstracts

Sokolov Y., Kozak J.A., Kayed, R., Chanturiya A., Glabe, C., Hall, J.E. (2006) Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure. J. General Physiol. 128:637.

Zhang, S.L., Yu, Y., Roos, J., Kozak, J.A., Deerinck, T.J., Ellisman, M.H., Stauderman, K.A., Cahalan, M.D.(2005) STIM1 is a Ca²⁺ sensor that activates CRAC channels and migrates from the Ca²⁺ store to the plasma membrane. Nature 437:902.

Kozak, J.A., Matsushita, M., Nairn, A.C., Cahalan, M.D. (2005) Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition and rundown of TRPM7/MIC channels. J. General Physiol. 126(5):499.

Matsushita M., Kozak J.A., Shimizu Y., McLachlin D.T., Yamaguchi H., Wei F.Y., Tomizawa K., Matsui H., Chait B.T., Cahalan M.D., Nairn A.C. (2005) Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. J. Biol. Chem. 280(21):20793.

Kozak J.A., Cahalan M.D. (2003) MIC channels are inhibited by internal divalent cations but not ATP. Biophysical Journal 84(2 Pt 1):922.

Kozak J.A. et al. (2002) Distinct Properties of CRAC and MIC Channels in RBL Cells. J. General Physiol. 120(2):221.

Perez C.A., Huang L., Rong M., Kozak J.A., Preuss A.K., Zhang H., Max M., Margolskee R.F. (2002) A transient receptor potential channel expressed in taste receptor cells. Nature Neuroscience 5(11):1169.

Kozak J.A. et al. (1998) Characterization of a Ca²⁺-activated K⁺ current in insulin-secreting murine βTC-3 cells. Journal of Physiology 509 (Pt 2):355.