Nancy Jane Bigley, Ph.D. Professor Address: 044 Biological Sciences Building Phone: (937) 775-2824 E-mail: nancy.bigley@wright.edu The Ohio State University, 1957

Research Interests:

The overall objective of my research is to understand the interactions between virus and the host defense system occurring between the first 12 to 24 hours of infection (innate immunity) which leads to susceptibility or resistance to disease (acquisition of adaptive immunity). The research projects under this objective deal with: a gender-based difference to the pathogenesis of a picornavirus [the D varoamt emce[tja;p,upcardotos voris {EMCV-D] and a DNA vaccine for HSV-1.

Selected Publications:

Rogers JV, Hull BE, Fink PS, Chiou HC, Bigley NJ (2000) Murine response to DNA encoding herpes simplex virus type-1 glycoprotein D targeted to the liver. Vaccine 18:1522-1530.

Cruz PE, Khalil PL, Dryden TD, Chiou HC, Fink PS, Berberich SJ, Bigley NJ (1999) A novel immunization method to induce cytotoxic T-lymphocyte responses (CTL) against plasmid-encoded herpes simplex virus type-1 glycoprotein D. Vaccine 17:1091-1099.

Mason KM, Bigley NK, Fink PS (1998) Development of a novel in vitro co-culture system for studying host response to native bacterial antigens. J Immunol Meth 211:147-158.

Curiel RE, Mason KM, Dryden TD, Maurer MJ, Bigley NJ (1998) Cytokines produced early in picornavirus infection reflect resistance or susceptibility to disease. J Interferon Cytokine Res 18:587-596.

Mason KM, Dryden TD, Bigley NJ, Fink PS (1998) Staphylococcal enterotoxin B primes cytokine secretion and lytic activity in response to native bacterial antigens. Infect Immun 66:5082-5088.

Curiel RE, Miller MH, Ishikawa R, Thomas DC, Bigley NJ (1993) Does the gender difference in interferon production seen in picornavirus-infected spleen cell cultures from ICR Swiss mice have any in vivo significance? J Interferon Res 13:387-395.