Extramural Research Grant Applications Currently Under Review
Updating Skeletal Maturity for U.S. Children
PI: Duren DL
CoI: Chumlea WmC
Funding Agency: NIH (AR055927-01)
Abstract: To update published methods of assessing skeletal age available to clinicians and other investigators of growth and maturation of children to include data from U.S. white children after 1980, and include data from U.S. black, Hispanic or Asian children. Aims: To update the FELS Method for assessing the skeletal age of the hand-wrist, to update the RWT Method for assessing the skeletal age of the knee, and to update the FELS and the RWT computer programs to current computer languages and to make web-based versions of these programs available.
Genetics of Joint Health and Risk of Osteoarthritis
PI: Duren DL
Funding Agency: NIH/NIAMS
Abstract: The primary goal of this study is to identify genes that influence the health and structure of the hand and knee joints throughout the adult lifespan.
Missing Data Methods for Longitudinal Studies with Outcome-Dependent Follow-Up
PI: Nahhas R
Co-Is: Czerwinski SA, Lee M, Tarpey T
Funding agency: NICHD, NIA
Submitted: 02/09
Total cost: $645,750
Abstract: The aims of this proposal are to develop statistical methods for longitudinal studies with non-ignorable continuous-time outcome dependent follow-up and to compare the performance of the developed methods with existing approaches using both real and simulated longitudinal data.
Longitudinal Changes in Hip Structure and Strength During Childhood
PI: Lee M
Co-Is: Czerwinski SA, Duren DL, Nahhas R
Funding agency:
Submitted: 02/09
Total cost: $143,500
Abstract: Using an existing database of areal DXA scans of the proximal femur, the Lifespan researchers will assess age-related changes in hip structure properties (section modulus and cross sectional area) of the femoral neck and shaft, and identify factors associated with patterns of change in structural parameters.
Genetics of Brain Structure and Function in the Fels Longitudinal Study
PI: Towne B
Co-Is: Czerwinski SA, Nahhas R, Lehrer DS
Funding agency:
Submitted: 02/09
Total cost: $4,037,304
Abstract: The goal of the proposed collaborative project is to identify genomic regions that influence variation in brain structure and function using high-density genome-wide association analysis in previously genotyped families from the Fels Longitudinal Study.
Genetics of Orofacial Cleft Endophenotypes and the Midface
PI: Sherwood R
Co-Is: Duren D, Skipper J, Towne B
Funding agency:
Submitted: 02/09
Total cost: $2,155,702
Abstract: The goal of the proposed study is particularly timely for public health. Deformities of the midface are among the most common congenital defects including many with significant health outcomes. Identifying the genes underlying normal variation in midface morphology will improve the ability to predict specific outcomes and provide important information for future gene therapy and tissue engineering treatments.
Adiponectin Subfractions, Carotid Intima Media Thickness and Associated Risk for Cardiovascular Disease
PI: Khalil N
Co-Is: Siervogel RM
Funding agency: AHA
Submitted: 02/09
Total cost: $88,000
Abstract: The post doctoral researcher and the Lifespan staff will seek to improve their understanding of the role of adiponectin subfractions with respect to dynamic changes associated with lipid metabolism, inflammation, and cardiovascular disease risk factors.
Genetic Architecture of the Human Dentognathic Complex
PI: Sherwood RJ
Co-Is: Duren DL, Subedi J, Towne B, VandeBerg JL, Williams-Blangero S
Funding agency: NIH (1R01DE018497)
Submitted: 03/08
Total cost: $3,401,889
Abstract: Significant health problems related to the dentition and jaws (the dentognathic complex) range from aesthetic issues due to malocclusion, to increase risk of caries, impaction, and infection due to dental crowding, to significant congenital deformities (e.g., orofacial clefting). The etiology of dentognathic disorders is complex. Both hereditary and environmental factors have been identified as factors influencing the variation of these traits. The proposed study is designed to examine normal variation in, and the relationships between, dentognathic traits in a population where environmental factors (diet, dental care) are relatively homogeneous.
Adiposity, Disease Risk Factors, and Lifetime Health
PI: Siervogel RM, Czerwinski SA
Co-I's: Chumlea WmC, Towne B, Duren D, Sherwood R, Lee Miryoung, Choh A, Nahhas R
Funding agency: NIH/NICHD (R01HD12252)
Submitted: 03/05/09
Total cost: $8,423,654
Abstract: This project involves the collection and analysis of long-term serial data from the Fels Longitudinal Study. Data are related to indices and measures of body fatness, adipose tissue distribution, lifestyle, lipids and lipoproteins, blood pressure, and other risk factors for cardiovascular disease. Analyses concern prediction of future states, associations among measures of body composition and other risk factors for cardiovascular disease, and patterns of change in individuals.
|
