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CURRENTLY OPEN CLINICAL TRIALS
Dayton Clinical Oncology Program accesses clinical trials through its membership
in
cooperative research groups funded by the National Cancer Institute (NCI),
and through the pharmaceutical industry.
For a listing of research groups and links to their web sites,
go to the "Links to Other Sites" tab at the left.
Clinical Trial By Disease Site
(Click the links to advance to a specific section)
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General Cancer Control Trials for Symptom Management
A221102 |
TitleStudy of Subcutaneous Testosterone in the Adjuvant Treatment of Postmenopausal Women with Aromatase Inhibitor Induced Arthralgias
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N08C9 |
Study of Sulfasalazine versus Placebo in the Prevention of Acute Diarrhea in Patients Receiving Pelvic Radiation Therapy
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S0702 |
Assess the Incidence of Osteonecrosis of the Jaw in Cancer Patients with Bone Metastases Starting Zometa Treatment.
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URCC-0701 |
Effects of Exercise on Cancer-Related Fatigue.
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URCC-10055 |
Assessment Of Cognitive Function In Breast Cancer And Lymphoma Patients Receiving Chemotherapy At Pre-Treatment, Post-Treatment And At Six Month Follow-Up |
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Information and Referral Form |
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BRAIN
TREATMENT:
N0872 |
Study of Either Dasatinib or Placebo Combined with Bevacizumab in Recurrent Glioblastoma
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N0877 |
Trial of Either Dasatinib or Placebo Combined With Standard Chemo-Radiotherapy for Newly Diagnosed Glioblastoma Multiforme (GBM)
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Brain Cancer Contol:
A221101 |
Randomized, Double-Blind Placebo Controlled Study of Armodafinil (Nuvigil®) To Reduce Cancer-Related Fatigue in Patients with Glioblastoma Multiforme
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BREAST
BREAST CANCER CONTROL:
NSABP B-43 |
Herceptin Given Concurrently with Radiation Therapy vs Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy
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S0927 |
Trial of Omega-3-Fatty Acid for the Control of Aromatase Inhibitor-Induced Musculoskeletal Pain and Stiffness in Women with Early Stage Breast Cancer
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S1105 |
Trial Of A Text-Messaging Intervention To Reduce Early Discontinuation Of Adjuvant Aromatase Inhibitor Therapy In Women With Early Stage Breast Cancer
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WFU-97609 |
Impact of Genomics and Exposures on Disparities in Breast Cancer Radiosensitivity
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HER2+:
BO25126 |
A randomized multicenter, double-blind, placebo-controlled comparison of chemotherapy plus trastuzumab plus placebo versus chemotherapy plus trastuzumab plus pertuzumab as adjuvant therapy in patients with operable HER2-positive primary breast cancer
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FB-7 |
A Phase II Randomized Clinical Trial Evaluating Neoadjuvant Therapy Regimens with Weekly Paclitaxel and Neratinib or Trastuzumab Followed by Doxorubicin and Cyclophosphamide with Postoperative Trastuzumab in Women with Locally Advanced HER2-Positive Breast Cancer
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METASTATIC:
8129 |
IMC-A12 in Combination With Temsirolimus in Patients With Metastatic Breast Cancer
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E2108 |
The Value of Early Local Therapy for the Intact Primary Tumor in Patients with Metastatic Breast Cancer
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E3108 |
Prospective Trial Correlating Progression Free Survival With CYP2D6 Activity in Patients With Metastatic Breast Cancer Treated With Single Agent Tamoxifen
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Nodal:
NSABP B-47 |
Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer
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NSABP B-49 |
Comparing the Combination of Docetaxel Plus Cyclophosphamide to Anthracycline-Based Chemotherapy Regimens for Women with Node-Positive or High-Risk
Node-Negative, HER2-Negative Breast Cancer
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NSABP B-51 |
Evauluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy
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S1007 |
Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer with Recurrence Score (RS) of 25 or Less
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GASTROINTESTINAL:
COLORECTAL CANCER PREVENTION:
GLNE 010 |
Validation and Comparison of Biomarkers for the Early Detection of Colorectal Adenocarcinoma
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NSABP P-5 |
Statin Polyp Prevention Trial in Patients with Resected Colon Cancer.
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OCCPI |
Ohio Colorectal Cancer Prevention Initiative: Universal Screening for Lynch Syndrome
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S0820 |
Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers for Patients with Stage 0-III Colon Cancer, Phase III - Preventing Adenomas of the Colon With Eflornithine and Sulindac (PACES)
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COLORECTAL TREATMENT:
CALGB-80702 |
6 versus 12 Treatments of Adjuvant FOLFOX Plus Celecoxib or Placebo for Patients With Resected Stage III Colon Cancer
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ESOPHAGEAL:
RTOG-1010 |
Evaluating The Addition Of Trastuzumab To Trimodality Treatment Of Her2-Overexpressing Esophageal Adenocarcinoma
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S1201 |
Evaluating Treatment for Patients Based on ERCC1 (Excision Repair Cross- Complementing 1) for Advanced/Metastatic Esophageal, Gastric or Gastroesophageal Junction (GEJ) Cancer
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LIVER:
CALGB-80802 |
Nexavar Plus Adriamycin vs Nexavar in Patients with Advanced Hepatocellular Carcinoma.
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PANCREATIC:
ACOSOG-Z5041 |
Preoperative Gemzar and Tarceva Plus Pancreatectomy and Postoperative Gemzar and Tarceva for Patients with Operable Pancreatic Adenocarcinoma.
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S1115 |
Trial of AZD6244 Hydrogen Sulfate (NSC-748727) and MK-2206 (NSC-749607) vs mFOLFOX in Patients With Metastatic Pancreatic Cancer After Prior Chemotherapy
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RECTAL:
N1048 |
Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision
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S0713 |
Oxaliplatin, Xeloda, Erbitux and Radiation in Pre-operative Therapy of Rectal Cancer.
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GENITOURINARY:
PROSTATE:
RTOG-1115 |
Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) with a GnRH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a GnRH Agonist and TAK-700 for Men with High Risk Prostate Cancer
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S1014 |
Abiraterone Acetate Treatment for Prostate Cancer Patients with a PSA of More Than Four Following Initial Androgen Deprivation Therapy
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S1216 |
Comparing Androgen Deprivation Therapy + TAK-700 With Androgen Deprivation Therapy + Bicalutamide in Patients With Newly Diagnosed Metastatic Hormone Sensitive Prostate Cancer
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RENAL:
E2810 |
Pazopanib vs. Placebo in Patients with Metastatic Renal Cell Carcinoma Who Have No Evidence of Disease Following Metastatectomy
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S0931 |
EVEREST: EVErolimus for Renal Cancer Ensuing Surgical Therapy
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S1107 |
Evaluation of ARQ 197 and ARQ 197 in Combination With Erlotinib in Papillary Renal Cell Carcinoma
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GYN:
GYN Cancer Control
GOG-0273 |
Chemotherapy toxicity in elderly women with ovarian, primary peritoneal or fallopian tube cancer
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Cervical
RTOG-1203 |
Study Of Standard Vs. IMRT Pelvic Radiation For Post-Operative Treatment Of Endometrial And Cervical Cancer ( Time-C)
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OVARIAN:
NCIC CTG OV.21 |
Intraperitoneal (IP) plus Intravenous (IV) Chemotherapy versus IV Carboplatin plus Paclitaxel in Patients with Epithelial Ovarian Cancer Optimally Debulked at Surgery following Neoadjuvant Intravenous Chemotherapy
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Head & Neck
RTOG-12616 Pending Approval |
Randomized Phase Ii/Iii Trial Of Surgery And Postoperative Radiation Delivered With Concurrent Cisplatin Versus Docetaxel Versus Docetaxel And Cetuximab For High-Risk Squamous Cell Cancer Of The Head And Neck
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LEUKEMIA:
AML:
E2906 |
Randomized Trial of Clofarabine as Induction and Post-Remission Therapy vs. Standard Daunorubicin & Cytarabine Induction and Intermediate Dose Cytarabine Post-Remission Therapy, Followed by Decitabine Maintenance vs. Observation in Newly-Diagnosed Acute Myeloid Leukemia in Older Adults (Age ≥ 60 Years)
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S1203 |
Study of Standard Cytarabine Plus Daunorubicin (7+3) Therapy or Idarubicin With High Dose Cytarabine (IA) Versus IA With Vorinostat (IA+V) in Younger Patients With Previously Untreated Acute Myeloid Leukemia (AML)
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LEUKEMIA OTHER:
551-1019 |
Open-label Study of MEDI-551 and Bendamustine vs Rituximab and Bendamustine in Adults With Relapsed or Refractory CLL
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E1908 |
Standard and Low Dose Rituximab: Initial Treatment of Progressive Chronic Lymphocytic Leukemia in Elderly Patients Using Alemtuzumab and Rituximab.
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LUNG:
NSCLC:
CALGB-30801 |
Trial Evaluating Selective Cox-2 Inhibition In Cox-2 Expressing Advanded Non-Small Cell Lung Cancer.
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E1505 |
Adjuvant Chemotherapy with or without Avastin for Patients with Completely Resected Stage IB(>=4 cm)-IIIA Non-Small Cell Lung Cancer.
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E5508 |
Study of Maintenance Therapy with Bevacizumab, Pemetrexed, or a Combination of Bevacizumab and Pemetrexed Following Carboplatin, Paxlitaxel and Bevacizumab for Advanced Non-Squamous NSCLC
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MO22097 |
An Open-Label, Randomized, Phase IIIb Trial Evaluating the Efficacy and Safety of Standard of Care +/- Continuous Bevacizumab Treatment Beyond Progression of Disease in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC) after First-Line Treatment with Bevacizumab Plus a Platinum Doublet-Containing Chemotherapy
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RC1126 |
Erlotinib Alone or in Combination with Bevacizumab in Patients with
Non-Small Cell Lung Cancer and Activating Epidermal Growth Factor Receptor Mutations
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S0819 |
Carboplatin/Taxol or Carboplatin/Taxol/Avastin with/without Concurrent Erbitux in Patients with Advanced Non-Small Cell Lung Cancer.
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SCLC:
IPM3002 |
| Palifosfamide-tris, A Novel DNA Crosslinker, in Combination with Carboplatin and Etoposide (PaCE) Chemotherapy versus Carboplatin and Etoposide (CE) Alone in Chemotherapy Naive Patients with Extensive-Stage Small Cell Lung Cancer. |
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Other:
S0905 |
Study of Cediranib (NSC#732208) versus Placebo in Combination With Cisplatin and Pemetrexed in Chemonaive Patients With Malignant Pleural Mesothelioma
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LYMPHOMA:
HODGKIN'S:
E2410 |
Response-Adapted Therapy Based on Positron Emission Tomography (PET) for Bulky Stage I and II Classical Hodgkin Lymphoma (HL)
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NON- HODGKIN
PIX306 |
Comparing Pixantrone + Rituximab with Gemcitabine + Rituximab in Patients with Aggressive B-cell Non-Hodgkin Lymphoma Who Have Relapsed after Therapy with CHOP-R or an Equivalent Regimen and are Ineligible for Stem Cell Transplant
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Lymphoma/Other
551-1088 (Temporarily Closed to accrual) |
Randomized Open-label Study of MEDI-551 in Adults With Relapsed or Refractory DLBCL
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CALGB-50904 |
Ofatumumab and Bendamustine vs. Ofatumumab, Bortezomib and Bendamustine in Patients with Untreated Follicular Lymphoma
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E1411 |
Four Arm Study In Patients ≥ 60 With Previously Untreated Mantle Cell Lymphoma Of Therapy With: Arm A = Rituximab+ Bendamustine Followed By Rituximab Consolidation (RB → R); Arm B = Rituximab + Bendamustine + Bortezomib Followed By Rituximab Consolidation (RBV→ R), Arm C = Rituximab + Bendamustine Followed By Lenalidomide + Rituximab Consolidation (RB → LR) or Arm D = Rituximab + Bendamustine + Bortezomib Followed By Lenalidomide + Rituximab Consolidation (RBV → LR)
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S0806 |
Vorinostat (SAHA) (NSC-701852) in Combination With Rituximab-CHOP in Patients With Newly Diagnosed Advanced Stage Diffuse Large B-Cell Lymphoma (DLBCL)
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S1001 |
PET-Directed Therapy for Limited Stage Diffuse Large B-cell Lymphoma (DLBCL)
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S1106 |
Trial of R-HCVAD/MTX/Ara-C Induction Followed by Consolidation With an Autologous Stem Cell Transplant vs. R-Bendamustine Induction Followed by Consolidation With an Autologous Stem Cell Transplant for Patients ≤ 65 Years of Age With Previously Untreated Mantle Cell Lymphoma
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MELANOMA:
E1609 |
A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon α-2b for Resected High-Risk Melanoma
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N0879 |
Carbo/Taxol/Avastin +/- Afinitor for Therapy of Metastatic Malignant Melanoma.
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MYELOMA:
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SARCOMA:
A091102 |
Study of MLN8237 in Advanced/ Metastatic Sarcoma
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A091103 |
Angiopoietin-1 and -2 peptibody amg 386 for the treatment of
Angiosarcoma
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OTHER:
A091104 |
Study of MK-2206 in patients with progressive, recurrent/metastatic adenoid cystic carcinoma
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N0392 |
Assessment of Patient Satisfaction with Participation on Phase II/III NCCTG Clinical Trials.
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QUESTIONS?
CONTACT DAYTON CLINICAL ONCOLOGY PROGRAM
OR ASK YOUR PHYSICIAN
"Is There a Clinical Trial For Me?"
Contact Us
By Phone:
(937) 775-1350
Fax:
(937) 775-1358
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By Mail:
Dayton Clinical Oncology Program
3123 Research Blvd., Suite 150
Dayton, Ohio 45420 |
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