Patrick B. Dennis, Ph.D. Adjunct Assistant Professor Genome Research Institute Email Dr. Dennis

Education:

Doctorate: 1993, The University of North Texas (Ruthann Masaracchia)
Postdoctoral: 1993-2001, Friedrich Miescher Institute, Switzerland (George Thomas)

Selected References:

Dennis, P. B., Jaeschke, A. J., Saito, M., Fowler, B., Kozma, S. C., & Thomas, G. (2001). Mammalian TOR: A homeostatic ATP sensor. Science, 294, 1102-1105.

Dennis, P. B., Fumagalli, S., & Thomas, G. (1999). Target of rapamycin (TOR): Balancing the opposing forces of protein synthesis and degradation. Curr. Op. Gen. Dev., 9, 49-54.

Dennis, P. B., Pullen, N., Pearson, R. B., Kozma, S. C., & Thomas, G. (1998). Phosphorylation sites in the autoinhibitory domain participate in p70s6k activation loop phosphorylation. J. Biol. Chem., 273, 14845-14852.

Pullen, N., Dennis, P. B.*, Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., & Thomas, G. (1998). Phosphorylation and activation of p70s6k by PDK1. Science, 279, 707-710. *Authorship shared.

Moser, B. A., Dennis, P. B., Pullen, N., Pearson, R. B., Williamson, N. A., Wettenhall, R. E. H., Kozma, S. C., & Thomas, G. (1997). Dual requirement for a newly identified phosphorylation site in p70s6k. Mol. Cell. Biol., 17, 5648-5655.

von Manteuffel, S. R., Dennis, P. B.*, Pullen, N., Gingras, A. C., Sonnenberg, N., & Thomas, G. (1997). The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k. Mol. Cell. Biol., 17, 5426-5436. *Authorship shared.

Jefferies, H. B. J. J., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B., & Thomas, G. (1997). Rapamycin suppresses 5' TOP mRNA translation through inhibition of p70s6k. EMBO J., 16, 3693-3704.

Dennis, P. B., Pullen, N., Kozma, S. C., & Thomas, G. (1996). The principal rapamycin-sensitive p70s6K phosphorylation sites, T-229 and T389, are differentially regulated by rapamycin-insensitive kinase-kinases. Mol. Cell. Biol., 16, 6242-6251.