Michael P. Markey, Ph.D.

Research Assistant Professor
Director, Center for Genomics Research

Lab: 104 Diggs lab
Office: 112 Diggs Lab
(937) 775-4536
Email: michael.markey@wright.edu

Education:

Doctoral: University of Cincinnati (Erik S. Knudsen)
Postdoctoral: Wood Hudson Cancer Research Laboratory (Taiping Chen)
Postdoctoral: Wright State University (Steven J. Berberich)

Research:

My research has focused on the molecular genetics of tumor suppressors, including genomics-based approaches for identifying transcriptional targets of RB and p53. As director of the WSU Center for Genomics Research, I hope to expand on my past research and continue in new directions.

Selected References:

Markey, M and Berberich, S. "hMdmX Transcripts are Reduced Following Genotoxic Stress." Manuscript in progress, December 2007.

Heminger, H, Markey, M, et al. "Alterations in gene expression and sensitivity to genotoxic stress following HdmX knockdown in human tumor cells harboring wild-type p53." Submitted Janurary 2007.

Markey, MP, Bergseid J, Bosco EE, Stengel K, Xu H, Mayhew CN, Schwemberger SJ, Braden WA, Jiang Y, Babcock GF, Jegga AG, Aronow BJ, Reed MF, Wang JY, Knudsen ES. "Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function." Oncogene (2007) 26, 6307-6318.

Chen, T., Jackson, C., Link, A., Markey, M., et al. "Int7G24A variant of transforming growth factor-beta receptor type I is associated with invasive breast cancer." Clinical Cancer Research. 2006 Jan 15;12(2):392-7.

Markey, M., et al. "Loss of the Retinoblastoma Tumor Suppressor: Differential Action on Transcriptional Programs Related to Cell Cycle Control and Immune Function." Submitted to Oncogene, December 2005.

Markey, M., et al. "Geminin is Targeted for Repression by the RB Pathway Through Intragenic E2F Sites." J Biol Chem. 2004 Jul 9;279(28):29255-62.

Angus, S., Mayhew, C., Solomon, D., Braden, W., Markey, M. et. al. "RB Reversibly Inhibits DNA Replication by Two Temporally Distinct Mechanisms." Mol Cell Biol. 2004 Jun;24(12):5404-20.

Markey, M. et al. "Unbiased Analysis of RB-Mediated Transcriptional Repression Identifies Novel Targets and Distinctions from E2F Action." Cancer Research. 2002 Nov 15; 62(22):6587-97.

Angus, S., Wheeler, L., Zhang, X., Markey, M., et al. "The Retinoblastoma Tumor Suppressor Targets dNTP Metabolism To Regulate Cell Cycle Progression." J Biol Chem. 2002 Nov 15;277(46):44376-84.

Angus, S., Fribourg, A., Markey, M., et al. "Active Rb Elicits Late G1/S Inhibition." Exp Cell Res. 2002 Jun 10;276(2):201-13.