Education:
Graduate School of Public Health, University of Pittsburgh (Infectious
Diseases and Microbiology)
Doctorate 1995 (University of Pittsburgh)
Post-doctorate (University of Pittsburgh)
 Research Interests:
Mutations in p63, a p53 related protein, are rare in human cancers but
have been shown to be prevalent in patients with ectrodactyly, ectodermal
dysplasia and cleft lip/palate (EEC) syndrome and split hand-split foot
malformations (SHFM). The goal of our laboratory is to identify genes
that are regulated by p63 that will provide new insights into the function
of p63 and its potential role in both development and cancer. Two projects
in the lab focuses on studying the regulation of Vitamin D Receptor and
Sonic Hedgehog signaling pathways, both of which play an important role
in both development and cancer, by p63. A third project involves studying
the effects of mutant forms of p63 on biological activity of p53 and
p63.
In addition to the projects on p63, our laboratory through our collaboration
with Air Force Research Laboratory, is involved in two DoD-funded projects.
The first project involves studying the effects of patterned silk film
cast from ionic liquids as scaffolds for cell growth and differentiation.
The other project involves use of hybrid nanostructures for studying
signal transduction and creating molecular scale diagnostic or sensing
devices.
Selected Publications:
Gupta MK, Khokhar SK, Phillips DM, Sowards LA, Drummy LF, Kadakia MP,
Naik RR Patterned Silk Films Cast from Ionic Liquid Solubilized Fibroin
as Scaffolds for Cell Growth Langmuir (In press)
Caserta TM, Kommagani R, Yuan Z, Robbins DJ, Mercer CA, Kadakia MP.
p63 overexpression induces the expression of Sonic Hedgehog. (2006) Mol
Cancer Res. Oct;4(10):759-68.
Heminger K, Jain V, Kadakia MP, Dwarakanath B, Berberich SJ. Altered
Gene Expression Induced by Ionizing Radiation and Glycolytic Inhibitor
2-Deoxy-Glucose in a Human Glioma Cell Line: Implications for Radio Sensitization.
(2006) Cancer Biol Ther. 11;5(7)
Kommagani R, Caserta TM, Kadakia MP. Identification of vitamin D receptor
as a target of p63. (2006) Oncogene. 22;25(26):3745-51.
Rozenzhak SM, Kadakia MP, Caserta TM, Westbrook TR, Stone MO, Naik
RR. Cellular internalization and targeting of semiconductor quantum dots.
(2005) Chem Commun. 7;(17):2217-9.
MP Kadakia, T. L. Brown, M. McGorry, and Berberich S.J. (2002) MdmX
inhibits Smad transactivation. Oncogene. 21(57):8776-85.
MP Kadakia, C. Slader, & S. J. Berberich. (2000) Regulation of
p63 function of Mdm2 and MdmX. DNA Cell Biol. 20(6):321-330
J. Goydos & MP Kadakia (1999). The Clinical Relevance of the Fas-FasL
Interaction. Cancer Therapeutics 2:107-112.
J. Goydos, MP. Kadakia, M. V. Tirabassi, D. Perez, & E. White.
(1999). Rendering Cells Resistant to Fas Ligand-Induced Apoptosis. Surgical
Forum. 50: 341-342
J. Goydos, , MP. Kadakia, M. V. Tirabassi, M. Doshi, D. Perez, & E.
White. (1999). Rendering Immune Effector Cells Resistant to Fas Ligand-Induced
Apoptosis. J. Surg. Res. 86:275
MP. Kadakia (1998). Human Herpesvirus 6 Infection and Associated Pathogenesis
Following Bone Marrow Transplantation. Leukemia and Lymphoma 31: 251-266.
M. Kadakia, W. B. Rybka, J. A. Stewart, J. L. Patton, F. R. Stamey,
M. Elsawy, P. E. Pellett, & J. A. Armstrong (1996). Human Herpesvirus
6: Infection and Disease Following Autologous and Allogeneic Bone Marrow
Transplantation. Blood 87: 5341-5354.
Lab Workers:
Not shown:
Joseph Van Nostrand, BMB master's student, and Angela Wagner, undergraduate
student |
